Table 2.
Summary of ASD like behavioral phenotypes of PZD mice.
| ASD feature | Test paradigm | PZD mice behavior |
|---|---|---|
| Impaired communication | Ultrasonic vocalizations male/female urine* | Impaired |
| Vocalization in reciprocal social interaction | Impaired | |
| Repetitive behavior | Self-grooming | Normal |
| Marble burying | Reduced (females) | |
| Y-maze | Normal | |
| Impaired social behavior | Nesting | Impaired |
| Sociability and social novelty test | Abnormal | |
| Olfactory habituation test | Normal | |
| Reciprocal social interaction | Abnormal / increased aggression | |
| Maternal behavior* | Impaired | |
| Resident intruder* | Increased aggression | |
| Anxiety | Open field | Increased |
| Elevated plus maze | Increased | |
| Activity | Open field | No hyperactivity |
| Cognitive impairment | Motor learning | Reduced |
*
were tested in (Grabrucker et al., 2014).