Table 1. The 30 possible treatment sequences in which subjects received a single 25-mg dose of omecamtiv mercarbil.

Sequence	Period 1 (days 1 – 6)	Period 2 (days 7 – 13)	Period 3 (days 14 – 20)	Period 4 (days 21 – 26)
1	IR fasting	MRT-F1 fasting	MRT-F1 fed	IR fed
2	MRT-F2 fasting	IR fasting	IR fed	MRT-F2 fed
3	IR fasting	MP fasting	MP fed	IR fed
4	SCT-F1 fasting	IR fasting	IR fed	SCT-F1 fed
5	IR fasting	SCT-F2 fasting	SCT-F2 fed	IR fed
6	MRT-F1 fasting	MRT-F2 fasting	MRT-F2 fed	MRT-F1 fed
7	MP fasting	MRT-F1 fasting	MRT-F1 fed	MP fed
8	MRT-F1 fasting	SCT-F1 fasting	SCT-F1 fed	MRT-F1 fed
9	SCT-F2 fasting	MRT-F1 fasting	MRT-F1 fed	SCT-F2 fed
10	MRT-F2 fasting	MP fasting	MP fed	MRT-F2 fed
11	SCT-F1 fasting	MRT-F2 fasting	MRT-F2 fed	SCT-F1 fed
12	MRT-F2 fasting	SCT-F2 fasting	SCT-F2 fed	MRT-F2 fed
13	MP fasting	SCT-F1 fasting	SCT-F1 fed	MP fed
14	SCT-F2 fasting	MP fasting	MP fed	SCT-F2 fed
15	SCT-F1 fasting	SCT-F2 fasting	SCT-F2 fed	SCT-F1 fed
16	MRT-F1 fed	IR fed	IR fasting	MRT-F1 fasting
17	IR fed	MRT-F2 fed	MRT-F2 fasting	IR fasting
18	MP fed	IR fed	IR fasting	MP fasting
19	IR fed	SCT-F1 fed	SCT-F1 fasting	IR fasting
20	SCT-F2 fed	IR fed	IR fasting	SCT-F2 fasting
21	MRT-F2 fed	MRT-F1 fed	MRT-F1 fasting	MRT-F2 fasting
22	MRT-F1 fed	MP fed	MP fasting	MRT-F1 fasting
23	SCT-F1 fed	MRT-F1 fed	MRT-F1 fasting	SCT-F1 fasting
24	MRT-F1 fed	SCT-F2 fed	SCT-F2 fasting	MRT-F1 fasting
25	MP fed	MRT-F2 fed	MRT-F2 fasting	MP fasting
26	MRT-F2 fed	SCT-F1 fed	SCT-F1 fasting	MRT-F2 fasting
27	SCT-F2 fed	MRT-F2 fed	MRT-F2 fasting	SCT-F2 fasting
28	SCT-F1 fed	MP fed	MP fasting	SCT-F1 fasting
29	MP fed	SCT-F2 fed	SCT-F2 fasting	MP fasting
30	SCT-F2 fed	SCT-F1 fed	SCT-F1 fasting	SCT-F2 fasting

IR = immediate release; MP = multiparticulate; MRT-F = matrix tablet; SCT-F = swellable core tablet.