Table 2. Formulation characteristics.

Formulation	Description
Immediate-release (IR) tablets	Manufactured via a conventional high-shear wet-granulation process
Matrix tablets (MRT-F1, MRT-F2)	Based on hydrophilic polymer matrix systems Release rate is controlled by the polymer concentration and its molecular weight Fumaric acid is incorporated in the matrix tablet to maintain a pH-independent drug release across the intestinal pH range
Multiparticulate capsule (MP)	Formulated with coated pellets, wherein the drug is contained in the pellet core Release rate of omecamtiv mecarbil from the pellets is modulated by two successively applied functional coatings that also provide minimal pH dependence of the release across the intestinal pH range
Swellable core tablets (SCT-F1, SCT-F2)	Consist of bilayer core tablets, film-coated with an insoluble, semipermeable membrane A laser-drilled hole on the drug layer side enables osmotic-based drug release Composition is the same for both formulations Rate control is achieved by altering the ratio of insoluble polymer and water-soluble plasticizer in the semipermeable coating