Table 1.
Characteristics of study.
| Study | Species (strain) | Sex | Age (m) | Anesthetic | Model (occlusion time) | IL-1Ra (mg/kg) | Dose times (min) | Lesion and functional outcome | Lesion/ oedema measure | Lesion measured | Oedema measured | Lesion/oedema measured (day) | Neurologicalscore (day) | Functional outcome (day) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Budapest 2013 | Mouse (C57 BL/6) | M | 2.5 | Isoflurane | Transient (Fil) 45 min | 100 s.c. | 30 + 180 | Y | Hist Stain (cresyl) | y | y | 7 | 1 + 7 (Bederson) | Corner 1 + 7 |
| Kuopio 2011 | Mouse (BALB/C) | M | 10 | Halothane | Permanent (Electrocoag) | 100 s.c. | 30 + 180 | Y | MRI | y | n | 3 + 28 | none | Catwalk 3 + 3 + 7 + 14 + 21 + 28 |
| M’chester 2012 | Mouse (BALB/C) | M | 2.5 | Isoflurane | Permanent (Electrocoag) | 100 s.c. | 30 + 180 | Y | MRI | y | y | 1 + 7 | 1 + 2 + 7 (Hunter) | Corner 1 + 2 + 7 |
| M’chester 2012 | Mouse (BALB/C) | M | 10 | Isoflurane | Permanent (Electrocoag) | 100 s.c. | 30 + 180 | Y | MRI | y | y | 1 + 7 | 1 + 2 + 7 + 28 (Hunter) | Corner 1 + 2 + 7 + 28 |
| M’chester 2010 | Mouse (C57 BL/6) | M | 2.5 | Isoflurane | Transient (Fil) 30 min | 100 s.c. | 30 + 180 | N | Hist Stain (cresyl) | y | n | 7 | none | none |
| M’chester 2011 | Mouse (C57 BL/6) | M | 2.5 | Isoflurane | Transient (Fil/Fil + TPA) 30 min | 100 s.c. | 30 + 180 | N | Hist Stain (cresyl) | y | y | 7 | 0 + 1 (21 point) | none |
| Caen 2012 | Mouse (C57 BL/6) | M | 2.5 | Isoflurane | Transient (Thrombin/ Thrombin + TPA) 30 min | 100 s.c. | 30 + 180 | N | Hist Stain (cresyl) | y | n | 7 | none | none |
| Lübeck 2011 | Mouse (C57 BL/6) | M | 2.5 | Tribro- methanol | Permanent (Electrocoag) | 100 s.c. | 30 + 180 | Y | Hist Stain (silver) | y | y | 7 | none | Corner 1 + 2 + 7 |