Table 2. Predictors of Restrictive Lung Disease in SSc Skin Subtypes.

	Unadjusted*		Adjusted Logistic Models**
			Demographics		Anti-Scl-70 Status		ACA Status		All Predictors
Type§	OR 95% CI	P	OR 95% CI	P	OR	P	OR	P	OR	P
0 vs. 2	0.5 [0.3, 0.8]	0.009	0.5 [0.3, 0.8]	0.009	0.9 [0.4, 2.1]	0.8	0.7 [0.3, 1.5]	0.3	0.8 [0.3, 2.1]	0.7
1 vs. 2	0.7 [0.5, 0.9]	0.02	0.6 [0.4, 0.9]	0.01	0.6 [0.4, 1.0]	0.045	0.7 [0.4, 1.1]	0.09	0.7 [0.4, 1.1]	0.09
3 vs. 2	1.5 [1.1, 2.1]	0.02	1.3 [0.9, 1.8]	0.2	1.1 [0.7, 1.8]	0.7	0.8 [0.5, 1.3]	0.3	0.8 [0.4, 1.3]	0.3
Scl-70	2.2 [1.6, 3.0]	<0.001	2.1 [1.5, 2.9]	<0.001	NA	NA	1.4 [1.0, 2.0]	0.045	1.6 [1.1, 2.2]	0.01
ACA	0.2 [0.2, 0.3]	<0.001	0.3 [0.2, 0.4]	<0.001	0.3 [0.2, 0.4]	<0.001	NA	NA	0.3 [0.2, 0.5]	<0.001
Muscle Disease	2.8 [2.0, 3.8]	<0.001	2.5 [1.8, 3.5]	<0.001	2.6 [1.8, 4.0]	<0.001	1.8 [1.2, 2.6]	0.006	1.9 [1.2, 2.9]	0.003

^*Simple logistic regression model used to determine the association of each predictor with the odds of developing RLD

^**Multiple logistic regression models controlling for demographics (including sex, age at onset, disease duration, race, and smoking status), Scl-70, ACA status or all predictors together.

^§Type 2 patients are used as a reference for to assessment of the relationship between SSc skin disease type and RLD risk. OR = odds ratio; 95% CI = 95% confidence interval; Scl-70 = topoisomerase I; ACA = anti-centromere; NA = not applicable