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. 2016 Mar 2;9:17. doi: 10.1186/s13045-016-0247-4

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© Bolomsky et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — PTC-209 inhibits osteogenesis via upregulation of DKK1. a PTC-209 significantly inhibited osteoblast formation in a dose-dependent manner verified by reduced alkaline phosphatase activity and matrix mineralization at days 14 and 21 of differentiation, respectively. Images are representative for three independent experiments. b Treatment with PTC-209 increased DKK1 expression in developing osteoblasts at day 14 of osteogenesis. c The inhibitory effect of PTC-209 on osteoblast activity was partially overcome by concurrent anti-DKK1 antibody treatment. ***P < 0.001, **P < 0.01 and *P < 0.05 vs DMSO control; ^# P < 0.05