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. 2016 Mar 3;13:56. doi: 10.1186/s12974-016-0522-x

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© Fang et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — The CM derived from Nogo/NgR-activated BV-2 microglia increased the expression and amyloidogenic processing of APP. Neurons were exposed for CM of BV-2 microglia at different treatments for 24 h. The expression of APP (a, b), BACE1 (a, c), ADAM10 (e, f), and PS1 loop (e, h) was determined using western blot. Values were reported as mean ± SD, as a percentage of values determined in the PBS group (control, 100 %). FRET assay was performed to detect the activity of β-secretase (d), α-secretase (g), and γ-secretase (i). Values were reported as mean ± SD, as a percentage of values determined in the PBS group (control, 100 %). *p < 0.05, **p < 0.01, ***p < 0.01, n = 3