Table 1.
Candidate SNPs
| SNP | Chr | Genotype* | HWP | Nearby gene(s): function |
|---|---|---|---|---|
| rs2155219 a | 11 | G/G: 0,30 G/T: 0,43 |
0.15 | C11orf30: Regulator, represses transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. LRRC32: Associated with allergic rhinitis and rhinitis |
| rs17616434 b | 4 | C/C: 0,06 C/T: 0,31 T/T: 0,62 |
0.371 | TLR10: Toll Like Receptor 10. Pathogen activation, activation innate immunity. TLR1: Toll Like Receptor 1. Specifically recognizes diacylated and triacylated lipopeptide. TLR6: Toll Like Receptor 6. This receptor functionally interacts with toll-like receptor 2. associated with an increased risk of asthma in some populations. FAM114A1: May play a role in neuronal cell development |
| rs6586513 a | 1 | A/A: 0,51 A/C: 0,49 |
0.15 | CROCC: Major structural component of the ciliary rootlet. Contributes to centrosome cohesion before mitosis. ATP13A2: ATPase Type 13A2. Transports inorganic cations and other substrates. SDHB: succinate dehydrogenase complex. Complex 2 of respiratory chain. MFAP2: Microfibrillar-associated protein. Major antigen of elastin-associated microfibrils |
| rs3860069 a | 4 | A/A: 0,50 A/C: 0,45 C/C: 0,05 |
0.343 | TLR6: Toll Like Receptor 6. This receptor functionally interacts with toll-like receptor 2. associated with an increased risk of asthma in some populations. TLR10: Toll Like Receptor 10. Pathogen activation, activation innate immunity. TLR1: Toll Like Receptor 1. Specifically recognizes diacylated and triacylated lipopeptide. FAM114A1: May play a role in neuronal cell development |
| rs6898653 a | 5 | A/A: 0,59 A/G: 0,36 G/G: 0,05 |
1 | SEMA6A: expression in developing neuronal tissue. Is required for proper development of the thalamocortical projection |
| rs2069772 a | 4 | A/A: 0,52 A/G: 0,38 G/G: 0,10 |
0.527 | IL2: Interleukin 2. Secreted cytokine for proliferation of T and B lymphocytes. Produced by T cells. ADAD1: binds to RNA. Plays a role in spermatogenesis. KIAA1109: associated with celiac disease |
Chr chromosome
* CEU genotype, NCBI database, HWP Hardy–Weinberg p value, NCBI database
acandidate SNP earlier reported by Ramasamy. A. 2011
bcandidate SNP earlier reported by Bønnelykke K. 2013