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. 2016 Feb 3;113(8):E958–E967. doi: 10.1073/pnas.1519680113

Fig. 1.

Fig. 1.

Cascade pathway, carbocation rearrangements, and deprotonated intermediates. The black box depicts the postulated carbocationic intermediates during the cascade pathway from GGPP→T and the numbering of the carbocation cascade steps. The red boxes depict the found deprotonated intermediates, whereby the red arrows indicate the cationic intermediate from which the deprotonated intermediate is derived. The structure in the middle depicts the conformation of productive GGPP (blue, double bonds in yellow) and the localization of the trinuclear Mg2+ cluster (green) in the active site of the closed TXS conformation. Note that numbering of cationic and deprotonated intermediates differs from previous reports (9, 11, 12, 15).