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. 2016 Feb 12;113(8):2258–2263. doi: 10.1073/pnas.1525564113

Fig. 4.

Fig. 4.

Repair junction signatures of TSS-proximal HTGTS junctions. (A) TSS-proximal HTGTS junction profiles (located within 2 kb of all TSSs) from Chr12-sgRNA-1–expressing NSPCs of the indicated genotypes. Joins with 0 (direct or “blunt” joins) to 10 bp of junctional MH were identified and plotted as a percentage of total junctions; insertions were excluded from the dataset. The number of independent experiments is indicated. Total junction numbers analyzed: n = 366 WT and n = 509 Xrcc4−/−p53−/− NSPCs. (B) The mean MH length of TSS-proximal HTGTS junctions indicated in bar graphs was determined in the indicated number of independent experiments. Data represent mean ± SEM; ***P < 0.001; **P < 0.01; *P < 0.05 (unpaired two-tailed t test).