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Repair junction profiles of TSS-proximal HTGTS junctions. (A) TSS-proximal (located within 2 kb of annotated TSSs) HTGTS junction profiles from Chr15-Myc-sgRNA–expressing NSPCs of the indicated genotypes; details are as in Fig. 4A. Total junction numbers analyzed: 421 WT and 374 Xrcc4−/−p53−/− NSPCs. (B) Mean MH length; details are as in Fig. 4B. Data represent mean ± SEM; ***P < 0.001; **P < 0.01; *P < 0.05 (unpaired two-tailed t test).
