Fig. 5.

Structure of SAE MATα2. (A) Superposition of MAT(α2)₂ with SAE bound (in purple) and SAMe bound (in silver) displayed as lines, showing no change in folding (rmsd 0.185 Å). (B) Superposition of SAE (light blue) and SAMe within the active site of MATα2, showing no change in position of surrounding residues. Residues from the SAMe bound structure are shown as silver sticks; those from the SAE bound structure, as purple sticks. Hydrogen bonds are shown as black dotted lines. (C) Omit map (Fo-Fc) electron density map and stick representation of SAE from MATα2. The map is contoured at the three sigma level around the SAE molecule.