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. 2016 Feb 8;113(8):2270–2275. doi: 10.1073/pnas.1600418113

Fig. 1.

Fig. 1.

Attenuated mechanical hypersensitivity of TNP in CaV3.1 KO mice after IoN ligation. (A) Schematic drawing of IoN ligations performed to induce TNP in mice. (Inset) Picture of two ligatures on IoN. (B) Mechanical sensitivity was robustly increased after the IoN ligations but not after sham operation. Although both genotypes displayed mechanical hypersensitivity (red asterisks, ***P < 0.001 by Student’s paired t test, before vs. 1 wk after IoN ligation in WT-TNP, n = 13; green asterisks, **P < 0.01 by Student’s paired t test, before vs. 1 wk after IoN ligations in KO-TNP, n = 13), CaV3.1 KO-TNP mice had an attenuated mechanical hypersensitivity, following 1-, 2-, and 3-wk IoN ligations, compared with WT (black asterisks, ***P < 0.001 by two-way repeated-measures ANOVA for genotype and postoperative time, WT-TNP vs. KO-TNP). Mechanical hypersensitivity was absent in sham-operated WT (n = 11) and KO (n = 12) mice. All values represent mean ± SEM.