Fig. S4.

(A) N1ICD OEx mice have lower levels of serum P4 but not E2 compared with control mice at 3.5 dpc. (B) Ovulation and fertilizing ability of oocytes showed no difference between N1ICD OEx mice and control mice. (C) Injection (s.c.) of P4 from 2.5 to 3.5 dpc can partially rescue expression of P4 targets in N1ICD OEx mice, but it is still significantly lower than that in control mice without supplemental P4 injection. (D) Supplemental P4 also does not alter estrogen signaling in OEx mice. (E) In the ovariectomized mouse model of exogenous treatment with P4 and E2 to mimic 3.5 dpc, the expressions of P4 targets are still significantly lower in OEx mice than in control mice. E2 targets are increased in OEx mice in the model described in F (n = 3–4 in each group). Ctrl, control. *P < 0.05; **P < 0.01.