Fig. 1. Circos plot of de novo mutations in ASD. All coding-sequence variants and copy-number variants present in AutismKB and SFARI Gene are shown. A GeneMANIA network analysis (centre) highlights proteins with synaptic function (36% of the proteins have at least one interaction with another protein, 61% are expressed in the brain, and 14% are known to be involved in synaptic function). From Huguet et al. 2013 (36).
