Table 1. Prevalence and biological pathways associated with ESSENCE.

Neurodevelopmental disorders	Prevalence%	Proteins or biological pathways
Learning disabilities	2–4	Chromatin remodelling Metabolism Actin skeleton organization Channels Synaptogenesis Neurotransmission
Dyslexia	5–15	Neuronal migration?
Attention deficit hyperactivity disorder	1.7–9	Synapses? Cortical maturation?
Autism spectrum disorders	0.6–1.2	Chromatin remodelling Metabolism Actin skeleton organization Channels Synapses
Epilepsy	0.45–1	Synapses Channels
Fetal alcohol syndrome	0.1–5	–