Table 3. Pharmacokinetic (PK) parameters of nefopam (n = 12).
| Nefopam 30 mg |
Nefopam 30 mg + modulated electro-hyperthermia |
||||
|---|---|---|---|---|---|
| PK parameter | Mean | SE | Mean | SE | p value |
| Cmax (ng/mL) | 32.18 | 3.16 | 42.42 | 5.32 | 0.0087 |
| AUClast (h × ng/mL) | 253.72 | 29.49 | 276.56 | 36.41 | 0.3654 |
| AUCinf (h × ng/mL) | 308.98 | 38.65 | 342.52 | 48.13 | 0.3411 |
| Tmax (h) | 2.08 | 0.21 | 1.58 | 0.23 | 0.0470 |
| t1/2 (h) | 8.47 | 0.82 | 9.40 | 0.97 | 0.1656 |
| CL/F (L/h) | 140.39 | 49.65 | 142.80 | 53.70 | 0.3411 |
| Vd/F (L) | 1198.71 | 140.19 | 1254.50 | 155.07 | 0.6194 |
Values are presented as the arithmetic mean. SE, standard error; Cmax, maxinum plasma concentration; AUClast, area under the plasma concentration-time curve until the final time point; AUCinf, area under the curve extrapolated to infinity; Tmax, time to Cmax; t1/2, terminal half-life; CL/F, apparent total clearance after oral administration; Vd/F, apparent volume of distribution after oral administration.