Table 4. Statistical analysis of nefopam (n = 12).
| Geometric LS mean |
Geometric LS mean ratio |
|||
|---|---|---|---|---|
| Pharmacokinetic parameter | Nefopam30 mg | Nefopam 30 mg + modulated electro-hyperthermia | Point estimate | 90% confidence interval |
| Cmax (ng/mL) | 29.65 | 37.97 | 1.2804 | 1.1155–1.4696 |
| AUClast (h × ng/mL) | 217.92 | 229.09 | 1.0512 | 0.9555–1.1566 |
| AUCinf (h × ng/mL) | 262.44 | 278.51 | 1.0612 | 0.9528–1.1819 |
These values are presented as the geometric means (CV%). The 90%CIs for parameters were within the bioequivalence limit of 0.8 to 1.25. The point estimate is geometric mean ratio. Cmax, maximum plasma concentration; AUClast, area under the curve until the final time point; AUCinf, area under the curve extrapolated to infinity
least-squares mean (LS).