Table 1.

RNA species detected in EV-RNA in different biological samples.

Study	Biological material	Method	RNA species
Valadi et al. 2007	Mast-cell line (MC/9), primary bone marrow–derived mast cells (BMMC), human mast-cell line (HMC-1)	Affymetrix microarray miRCURY™ LNA Array	mRNA (including polyadenylated fraction) miRNA
Skog et al. 2008	Primary glioblastoma multiforme cells Matched glioblastoma tumor and serum	Agilent whole human genome microarray, 4 ×44K Nested PCR	mRNA (including EGFRvIII mutant) miRNA
Balaj et al. 2011	Primary glioblastoma cell lines 20/3 and 11/5	Agilent whole human genome microarray, 4 ×44K	mRNA (including c-Myc amplification) human endogenous retroviruses (HERVs)
	Primary medulloblastoma cell lines D458, D384 and D425
	Rhabdoid tumor cell line NS224
	Melanoma cell line, Yumel 0106
	Epidermoid carcinoma cell line, A431
	Human fibroblast lines, HF19 and HF27, Serum from xenograft mouse model of medulloblastoma
Bellingham et al. 2012	Mouse hypothalamic neuronal (GT1–7) cell lines GT1–7 cells infected with human Fukuoka-1 prion strain	Small RNA deep sequencing	mRNA, RNA repeats, rRNA, small RNA (Transfer RNA (tRNA), small interfering (siRNA), small nucleolar RNA (snoRNA), small cytoplasmic RNA (scRNA), small nuclear RNA (snRNA), miRNA
Huang et al. 2013	Human plasma	Small RNA deep sequencing	miRNA, lncRNA, tRNA, snoRNA, snRNA, piwi-interacting RNA (piRNA), mRNA
Eirin et al. 2014	Porcine adipose tissue–derived mesenchymal stromal/stem cells	RNA deep sequencing	mRNA, rRNA, miRNA