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Methods of extracellular vesicles quantification.
| Technique | Feature |
|---|---|
| Protein Concentration Assay | Biased because of copelleted protein aggregates |
| Nanoparticle tracking analysis (NTA) | Can be used for small EVs (i.e., less than 500 nm) |
| Conventional flow cytometry | Suitable for large EVs (more than 500 nm), however can be biased by immune complexes from peripheral blood |
| Modified flow cytometry with membrane dye | Applicable for EVs larger than 100 nm |
