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The importance of receptor flexibility has become more obvious with the increase of structural data. For instance, pictured here is an overlay of an apo (PDBID: 1AHC in green) and holo (PDBID: 1AHB in blue and grey) structure of alpha-Momorcharin. There is a steric clash between the ligand and the apo structure that would prevent rigid docking methods from predicted the crystallographic conformation.
