Figure 1.

The white-opaque regulatory circuitry. (A) Typical white and opaque cells, each grown in the same liquid culture medium. Scale bar is 5 µm. (B), (C) Regulatory circuit in white (B) and opaque (C) cells based on binding events identified in previously published ChIP-chip studies of key regulators of switching (Zordan et al. 2007; Hernday et al. 2013; Lohse et al. 2013). Genes upregulated in a given cell type are shown in black with white text, with downregulated genes in white with black text. Genes that are not differentially regulated between cell types are shown in gray. Arrows represent direct binding interactions to the regulatory region of a given gene.