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. 2015 Oct 25;3(6):e00180. doi: 10.1002/prp2.180

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© 2015 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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(A) Caffeine reduces mononuclear phagocyte aggressiveness in noncaffeine drinkers at 100 μmol/L (P = 0.0480) and 750 μmol/L (P = 0.0116). Differences report was generated using a matched pair t‐test. n = 6. (B) With caffeine drinkers’ mononuclear phagocytes, there was no significant difference in aggressiveness in any concentration or with PKA inhibitor except a small difference between the control and control + PKA inhibitor (P = 0.0439). This could be due to the inhibition of caffeine already in the serum of these patients. Data generated using a matched pair t‐test. n = 5.