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. 2015 Oct 25;3(6):e00180. doi: 10.1002/prp2.180

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© 2015 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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(A) Noncaffeine drinkers’ mononuclear phagocytes show significant reductions in aggressiveness when treated with either 100 μmol/L (P = 0.0314) or 750 μmol/L caffeine (P = 0.0037). Addition of PKA inhibitor reversed this reduction for 100 μmol/L caffeine, but not totally for 750 μmol/L caffeine (P = 0.0117). Data generated using a matched paired t‐test. n = 6. (B) Caffeine drinkers’ mononuclear phagocytes show no sensitivity to caffeine at 100 or 750 μmol/L concentrations. PKA inhibitor also had no effect on these cells’ aggressiveness. Data generated using a matched paired t‐test. n = 5.