Table 1.

Target genes selected for mRNA expression analysis

Gene name	Protein product	Function	Studies implicating gene in antidepressant response
Nr3c1	Glucocorticoid receptor	Receptor for glucocorticoids, such as corticosterone in mice	Peiffer et al. (1991), Seckl and Fink (1992), Johansson et al. (1998), Bjartmar et al. (2000), Guidotti et al. (2013)
Nr3c2	Mineralocorticoid receptor	Cytosolic receptor for mineralocorticoids, such as aldosterone, as well as glucocorticoids	Brady et al. (1991), Seckl and Fink (1992), Johansson et al. (1998), Bjartmar et al. (2000)
Fkbp5	FK506‐binding protein	Immunophilin protein involved in immunoregulation and protein folding/trafficking	Guidotti et al. (2013)
Egr1	Early growth response protein 1 (aka Zif268 or NGFI‐A)	Transcription factor	Morinobu et al. (1997), Johansson et al. (1998), Bjartmar et al. (2000), Sillaber et al. (2008)
Nr4a1	Nerve growth factor IB	Transcription factor	Bjartmar et al. (2000)
Slc6a4	Serotonin transporter	Reuptake of 5‐HT from synaptic space	Lesch et al. (1993), Lopez et al. (1994), Benmansour et al. (1999)
Tph2	Tryptophan hydroxylase 2	Rate limiting enzyme in the synthesis of 5‐HT in CNS	Abumaria et al. (2007), Shishkina et al. (2007), Heydendael and Jacobson (2009)
Htr1a	5‐HT1A receptor	5‐HT autoreceptor involved in regulation of 5‐HT signaling	Burnet et al. (1994), Abumaria et al. (2007)
Kcnk2	Trek‐1	Potassium channel	Heurteaux et al. (2006)
Bdnf	Brain‐derived neurotrophic factor	Neurotrophin	Nibuya et al. (1995), Martinez‐Turrillas et al. (2005), Sillaber et al. (2008), Alboni et al. (2010)
Creb	cAMP response element‐binding protein	Transcription factor	Nibuya et al. (1996), Thome et al. (2000), Blom et al. (2002), Alboni et al. (2010)
S100a10	p11	Involved in regulation of 5‐HT signaling in brain	Svenningsson et al. (2006), Melas et al. (2012)