Table 2.
Differences in HER2 expression, by clinicopathologic characteristic
| Characteristic | HER2 expression negative (n=405) |
HER2 expression positive (n=273) |
P-value |
|---|---|---|---|
| Age, years | 0.16 | ||
| <60 | 221 | 134 | |
| ≥60 | 184 | 139 | |
| Sex | 0.04 | ||
| Male | 259 | 195 | |
| Female | 146 | 78 | |
| Tumor location | 0.001 | ||
| Upper third | 107 | 108 | |
| Middle third | 108 | 62 | |
| Lower third | 190 | 103 | |
| Tumor size, cm | 0.63 | ||
| <5 | 275 | 179 | |
| ≥5 | 130 | 94 | |
| Histological grade | ,0.001 | ||
| Well-differentiated | 57 | 75 | |
| Poorly differentiated | 348 | 198 | |
| Histological type | 0.004 | ||
| Intestinal type | 80 | 68 | |
| Diffuse type | 175 | 75 | |
| Mixed type | 45 | 31 | |
| TNM stage | 0.67 | ||
| I | 84 | 51 | |
| II | 109 | 81 | |
| III | 212 | 141 | |
| Adjuvant chemotherapy | 0.54 | ||
| Yes | 297 | 206 | |
| No | 108 | 67 | |
| CEA | 0.06 | ||
| Normal | 307 | 175 | |
| Elevated | 71 | 59 | |
| CA19-9 | 0.58 | ||
| Normal | 321 | 190 | |
| Elevated | 44 | 30 | |
| CA72-4 | 0.78 | ||
| Normal | 294 | 176 | |
| Elevated | 74 | 47 | |
| VEGF expression | 0.008 | ||
| Positive | 159 | 80 | |
| Negative | 246 | 193 |
Abbreviations: CA, carbohydrate antigen; CEA, carcinoembryonic antigen; HER2, human epidermal growth factor receptor 2; TNM, tumor–node–metastasis; VEGF, vascular endothelial growth factor.