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. 2016 Feb 26;10:851–859. doi: 10.2147/DDDT.S97380

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© 2016 Dang et al. This work is published and licensed by Dove Medical Press Limited

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PAP modulated microglial phenotype transformation.

Notes: Cells were pretreated with PAP (0, 2, and 10 μg/mL) for 4 hours and incubated with LPS (100 ng/mL) for an additional 24 hours. The transcription of IL-1ra (Il1rn), SOCS3 (Socs3), Arg1 (Arg1), and CD206 (Mrc1) was measured by RT-PCR. (A and B) Shows PAP pretreatment significantly inhibited the transcription of M2b-associated markers IL-1ra (Il1rn), SOCS3 (Socs3) *P<0.01, but upregulated the transcription of M2a-associated markers Arg1 (Arg1) and CD206 (Mrc1) (C and D) *P<0.05. The results are represented as the mean ± SD of three independent experiments.

Abbreviations: PAP, papaverine; LPS, lipopolysaccharide; RT-PCR, reverse transcriptase polymerase chain reaction; SD, standard deviation; CON, control.