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. 2016 Jan 15;4(1):e00207. doi: 10.1002/prp2.207

Figure 3.

Figure 3

Apixaban and CPD1 effects on thrombosis (AVS) and bleeding (CBT) in the rats. (A) Apixaban and (B) CPD1 effects on thrombosis and primary hemostasis. (C) Separation of bleeding curves for apixaban and CPD1 at equivalent antithrombotic activity. *P < 0.05, **P < 0.01, ***P < 0.0001 versus vehicle control. B, bolus; I, infusion; Apix, apixaban; Apixaban (A1) 0.1 mg/kg bolus followed by 0.12 mg/kg infusion; (A2), 0.3 mg/kg followed by 0.375 mg/kg; (A3) 1 mg/kg followed by 1.25 mg/kg; (A4) 3 mg/kg followed by 3.75 mg/kg; (A5) 8 mg/kg followed by 10.2 mg/kg. CPD1; (C1) 0.06 mg/kg bolus followed by 0.09 mg/kg infusion; (C2) 0.2 mg/kg followed by 0.3 mg/kg; (C3) 0.6 mg/kg followed by 0.9 mg/kg; (C4) 2 mg/kg followed by 3 mg/kg; (C5) 6.5 mg/kg followed by 9.8 mg/kg. CPD1, compound 1; AVS, arteriovenous shunt; CBT, cuticle bleeding time.