Table 2.
Inhibitory effects of FF‐10501RMP, FF‐10501, and mycophenolic acid on the enzyme activities of IMPDH1 and IMPDH2
| Compound | IMPDH1 | IMPDH2 |
|---|---|---|
| (A) | IC50 (nmol/L) | |
| FF‐10501RMP | 29.0 ± 10.3 | 31.8 ± 5.6 |
| Mycophenolic acid | 26.4 ± 1.5 | 27.8 ± 8.3 |
| (B) | Enzyme activity inhibition (%) | |
| FF‐10501, 1000 nmol/L | 12.4 ± 11.5 | −6.2 ± 6.4 |
| FF‐10501, 10,000 nmol/L | 5.6 ± 16.6 | −11.1 ± 9.8 |
(A) IC50 values of FF‐10501RMP and mycophenolic acid against IMPDH1 and IMPDH2 were analyzed. (B) Enzyme activity inhibition (%) of FF‐10501 against IMPDH1 and IMPDH2 were measured. The data are the means of three independent measurements ± SD.