Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Feb 26;11:791–822. doi: 10.2147/IJN.S97476

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 Spadavecchia et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

Determination of LC₅₀ and EC₅₀ values.

Notes: (A) Percentage of live cells as quantified by flow cytometry after exposing PANC-1 cells to various concentrations of PEG-AuNPs (ranging from 0 to 2.5×10⁻⁴ M) for 24 hours. Dose–response curves are fitted to extrapolate the LC₅₀ value of PEG-AuNPs. (B) LC₅₀ values of PEG-AuNPs as extrapolated from dose–response curves. (C) Percentage of live cells as quantified by flow cytometry after exposing PANC-1 cells to various concentrations of DOX (ranging from 0 to 8 μM) for 24 hours. The dose-response curve is fitted to extrapolate the EC₅₀ value of DOX. The scale bar is not comparable to graph (A). (D) Comparison among the EC₅₀ values of doxorubicin loaded onto AuPEG_3, AuPEG_4, or tested in its molecular form (DOX). (B, D) LC₅₀ and EC₅₀ values are reported as mean ±95% confidence interval.

Abbreviations: PEG, polyethylene glycol; AuNPs, gold nanoparticles; LC₅₀, half-maximal lethal concentration; DOX, doxorubicin; AuPEG, PEG-coated AuNPs; EC₅₀, half-maximal effective concentration.