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. 2016 Mar 3;11(3):e0150665. doi: 10.1371/journal.pone.0150665

Fig 1. The sexually dimorphic circadian pattern of plasma CORT is differentially altered in male and female Lxrα-/- mice.

Fig 1

(A) Rhythm of plasma CORT was determined in wild type (plain line) and Lxrα-/- (dashed line) male mice entrained to a LD12:12 cycle. (B) Same as in (A) except that mice were females. Cosinor based non-linear regression was used for curve fitting. Plotted data were from 10 mice for each experimental group. The ZT0 time point is double plotted for visualization purpose. White and black bars represent the light and dark phases, respectively. Statistically significant differences in cosine fitting parameters (p<0.05) between wild type and Lxrα-/- mice or between male and female of the same genotype is indicated in the grey box at the top of the corresponding graph or between graphs (WT: plain arrow, Lxrα-/-: dashed arrow). µ, α and φ indicate a difference in mean level, amplitude and acrophase, respectively.