Table 1. Cosinor analysis of plasma CORT circadian pattern in WT and Lxrα -/- mice.
Group | Mean level (ng/ml) | Amplitude | Acrophase (ZT:min) |
---|---|---|---|
♂ WT | 206.7 (181.4 ; 231.2) | 94.9 (62.5 ; 129.0) | 12:16 (10:49 ; 13:47) |
♂ Lxrα -/- | 274.0 (235.8 ; 317.0)† | NSR | NSR |
♀ WT | 437.6 (388.7 ; 486.5)* | 114.7 (62.5 ; 179.4) | 12:24 (09:49 ; 14:52) |
♀ Lxrα -/- | 545.4 (458.3 ; 634.3)* | 356.6 (225.1 ; 492.1)*† | 13:03 (11:52 ; 14:23)* |
For each parameter measured, values are represented as median ± 95% bootstrap confidence intervals.
* indicates significant differences between females vs males
† indicates significant differences between Lxrα-/- vs WT mice.
Circadian rhythmicity was considered significant for a p-value < 0.05; NSR, not significantly rhythmic.