Table 3. Cosinor analysis of Cyp7α1 circadian expression in WT and Lxrα-/- mice.
Gene | Group | Amplitude | Acrophase (ZT:min) | |
---|---|---|---|---|
Cyp7 α 1 | ♂ WT | 0.81 (0.64 ; 1.01) | 0.41 (0.18 ; 0.70) | 19:18 (16:22 ; 21:43) |
♂ Lxrα-/- | 0.58 (0.45 ; 0.74) | 0.30 (0.12; 0.52) | 9.21 (6:24; 12:35)† | |
♀ WT | 1.83 (1.53 ; 2.15)* | NSR | NSR | |
♀ Lxrα-/- | 0.90 (0.64 ; 1.18)† | 0.52 (0.20; 0.96) | 9.37 (6:29; 12:33) |
Values are represented as median ± 95% bootstrap confidence intervals.
* indicates significant differences between females vs males
† indicates significant differences between Lxrα-/- vs WT mice.
Circadian rhythmicity was considered significant for a p-value < 0.05; NSR, not significantly rhythmic.