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. Author manuscript; available in PMC: 2016 Mar 3.
Published in final edited form as: Biochemistry. 2015 Oct 8;54(41):6333–6342. doi: 10.1021/acs.biochem.5b00930

Fig. 5. Helix α2 is “unraveled” in 5-LOX.

Fig. 5

Helix α2 of 15-LOX-2 (light green), superimposed on 5-LOX (pink), displays the typical orientation for lipoxygenases with open-access active sites. Note that the counterpart of 5-LOX F177 (F184) in 15-LOX-2 does not occupy the same position as F177. The competitive inhibitor of 15-LOX-2 (C8E4) is shown in green stick. The 15-LOX-2 counterparts of 5-LOX D170, G174 and R401 are also included. N181 is on the backside of the helix and not visible from this perspective. 15-LOX-2 residues are labeled in italics.