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. Author manuscript; available in PMC: 2016 Mar 3.
Published in final edited form as: Biochemistry. 2015 Oct 8;54(41):6333–6342. doi: 10.1021/acs.biochem.5b00930

Fig. 6. Anomalous placement of the corking residues in 5-LOX.

Fig. 6

5-LOX “corking” amino acids (bright blue, F177,Y181) are displaced relative to their counterparts F175, L179 in 15-LOX (lavender, 2P0M); F175, L179 in 12-LOX (gold, 3RDE); F184, A188 in 15-LOX-2 (green, 4NRE) and Y178, R182 in 8R-LOX (white). AA (white) and 12-LOX (orange) and 15-LOX-2 (pink) inhibitors are rendered in sticks. For reference, the catalytic iron (red sphere) and 5-LOX residues A603 and H600 are included.