Figure 2.

a) Comparison of immunofluorescence staining of permeabilized and non-permeabilized WT and Neu1−/− macrophages with LAMP1 antibodies against either the C-terminal cytosolic domain (L1418) or the glycosylated luminal domain (1D4B) of LAMP1; b) Bone sections from 2 months old Neu1−/− and control mice were stained with the anti-VCAM-1; Strong immunoreactivity was observed only in the sections from the control in the region lining the bone (arrows). Adapted from Yogalingam et al Dev. Cell 2008, with permission of Elsevier.