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. Author manuscript; available in PMC: 2016 Aug 27.
Published in final edited form as: J Med Chem. 2015 Aug 18;58(16):6589–6606. doi: 10.1021/acs.jmedchem.5b00710

Table 5.

Pharmacokinetic properties of 9

ID route Dose (mg/kg) Tmax (h)a Cmax (ng/mL)b AUClast (h*ng/mL)c T1/2 (h)d CL (mL/min/kg)e Vss (L/kg)f F (%)g
9 IV 2 158.56 241.30 1.40 135.88 18.38
PO 10 0.5 204.25 795.29 66
a

Time for peak plasma concentrations.

b

Peak plasma concentrations.

c

Area under the concentration time curve.

d

Terminal half-life.

e

Plasma Clearance.

f

Volume in steady state.

g

Bioavailability.