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Toxicities by grade and elicited consensus severity weight used for adaptive dose-finding.
| Type of Toxicity | Grade | Elicited Consensus Severity Weight |
|---|---|---|
| Myelosuppression without fever | 3 | 1.0 |
| 4 | 1.5 | |
| Myelosuppression with fever | 3 | 5.0 |
| 4 | 6.0 | |
| Dermatitis | 3 | 2.5 |
| 4 | 6.0 | |
| Hepatotoxicity | 2 | 2.0 |
| 3 | 3.0 | |
| 4 | 6.0 | |
| Nausea / Vomiting | 3 | 1.5 |
| 4 | 2.0 | |
| Fatigue | 3 | 0.5 |
| 4 | 1.0 |
