Fig 3. Evidence for a glycolytic switch in the MCT-treated rat lung.

Data for control lung are represented in grey boxes and data for the pre-PH lung are represented in blue boxes. Quantities are in arbitrary units (N = 10, p<0.05). MCT-treated animals have higher levels of glucose, glucose-6-phosphate, glucose-1-phosphate, fructose, fructose-6-phosphate, 6-phospho gluconate, ribulose 5-phosphate, sedoheptulose-7-phosphate, pyruvate and lactate. These metabolic data are consistent with an upregulation of glycolytic or glucose dependent pathways in the lungs of pre-PH rats.