Fig 10. Evidence of a redox imbalance in the MCT-treated rat lung.

Despite an increase in glutathione recycling, as indicated by increases in the 5-oxoproline metabolite, both reduced and oxidized glutathione are significantly decreased in the pre-PH (A), indicative of increased oxidative stress. The ratio between pre-PH and control metabolites demonstrate significant increases (red boxes) gamma-glutamyl amino acids (B). Activation of the gamma-glutamyl cycle is usually associated with an increased inflammatory response (N = 10, p<0.05).