Table 1. Tissue-capillary system particulars.

Parameter	Definition	Source
LRBC = 200 μm	RBC region length	[20]
LCFR = 200 μm	Cell-free region length	[20]
LTissue = 200 μm	Cerebral tissue length	[20]
RRBC = 3.25 μm	RBC (erythrocyte) region radius	[21]
tCFR = 0.75 μm	Cell-free region (CFR) thickness	[21]
tTissue = 25 μm	Brain tissue thickness	[22]
ρRBC = 1,160 kg/m3	RBC mass-density	[23]
ρCFR = 1,025 kg/m3	Cell-free region (plasma) mass-density	[24]
ρTissue = 1,040 kg/m3	Brain tissue mass-density	[25]
μCFR = 1.2 × 10−3 kg/m-s	Cell-free region dynamic viscosity	[23]
DO2RBC = 8.8 × 10−6 cm2/s	RBC O2 diffusivity	[26, 27]
DO2CFR = 2.29 × 10−5 cm2/s	Cell-free region (plasma) O2 diffusivity	[13, 28]
DO2Tissue = 1.6 × 10−5 cm2/s	Brain tissue O2 diffusivity	[27]
DHb = 1.42 × 10−7 cm2/s	RBC hemoglobin diffusivity	[13, 29]
CBv = 0.3–1.2 mm/s	Capillary blood velocity	[30–32]
CMRO2 = 200–466i	Metabolic rate of O2 utilization	[27, 33, 34]
cH = 9.1 mol/m3	Oxygen carrying capacity of Hb	[32]
kH = 40 s−1	Reaction rate of HbO2 dissociation	[35]
${\mathcal{H}}_{{\text{O}}_2}=769.2\text{L-atm/mol}$	Henry’s law (oxygen) constant	[36]
$n=\frac{\Delta \text{CBF}/\text{CBF}}{\Delta {\text{CMR}}_{{\text{O}}_2}/{\text{CMR}}_{{\text{O}}_2}}$	Normalized ΔCBF to ΔCMRO2	–
$m=\frac{\Delta \text{CBv}/\text{CBv}}{\Delta {\text{CMR}}_{{\text{O}}_2}/{\text{CMR}}_{{\text{O}}_2}}$	Normalized ΔCBv to ΔCMRO2	This study
HT = 0.31	Tube hematocrit	[37]

ⁱUnits: μmol/100g/min.