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. 2016 Mar 3;11(3):e0150450. doi: 10.1371/journal.pone.0150450

Fig 2. NR4A1 binding sites at induced and repressed genes display differential preference for DHS regions.

Fig 2

(A) NR4A1 binding sites associated with induced (red) and repressed (green) genes within DHS regions (blue) from Kasumi-1 cells. (B,C) Examples of NR4A1 ChIP-seq occupancy (green) and DHS profiles (black) at genes upregulated (B) and repressed (C) by NR4A1. Arrows denote NR4A1 binding peaks without DHS at upregulated genes and NR4A1 binding peaks with DHS at repressed genes. The y axis represents cumulative tag counts at each region, and RefSeq transcripts are shown below. (D) Overlap of NR4A1 binding sites at upregulated (red) and downregulated (green) genes with ERG/FLI-1 binding sites identified in SKNO-1 cells (blue). (E,F) Venn diagram representing overlap between NR4A1 binding sites within non-DHS (E) or DHS (F) regions at induced (red) and repressed (green) genes and ERG/FLI-1 binding sites in Kasumi-1 cells.