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. 2016 Mar 3;11(3):e0150450. doi: 10.1371/journal.pone.0150450

Fig 3. NR4A1 directly regulates expression of cell developmental and cellular proliferation genes.

Fig 3

(A) Summary of enriched GO terms for directly upregulated genes using DAVID functional annotation. (B) RT-qPCR validation of NR4A1-dependent induced genes at 6hr (sample size = 3). (C) ChIP-qPCR analysis of NR4A1 recruitment to induced genes in Kasumi-1 cells at 4hr (sample size = 3). (D) Gene ontology annotations associated with repressed genes. (E) RT-qPCR validation of repressed genes at 6hr (sample size = 3). (F) ChIP-qPCR analysis of NR4A1 recruitment to repressed genes at 4hr in Kasumi-1 cells (sample size = 3). NT = non-transcribed region in a gene desert of chr7. Results are means ± s.d. **p<0.01, *p<0.05.