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Scrophularia orientalis extracts induce opening of the mitochondrial permeability transition pore (MPTP). MYCN2 cells were grown for 48 h. The last 24 h of the experiment cells were treated with 8 μg/ml of extract 35D. Cells were loaded with calcein-AM, CoCl2 and Mitotracker. Opening of MPTP by 35 was measured for co-localization/loss of mitochondrial calcein levels.
