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Mitochondrial Parameters and Treatment
| n | DOX Median (range) | n | DEX+DOX Median (range) | P-value | |
|---|---|---|---|---|---|
| MtDNA copies/cell | 27 | 1106.3 (144.2-6746.8) | 35 | 310.5 (15.3-1859.2) | 0.001 |
| CI activity (OD/μg × 103) | 25 | 10.5 (5.0-31.3) | 33 | 11.7 (5.0-41.4) | 0.97 |
| CIV activity (OD/μg × 103) | 25 | 9.8 (5.0-20.1) | 34 | 8.1 (4.7-23.4) | 0.40 |
CI, Complex I; CIV, Complex IV; DOX, doxorubicin; DEX, dexrazoxane; DEX+DOX, administration of dexrazoxane prior to every doxorubicin treatment; OD, optical density.
