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. Author manuscript; available in PMC: 2017 Mar 2.
Published in final edited form as: Neuron. 2016 Feb 18;89(5):1059–1073. doi: 10.1016/j.neuron.2016.01.023

Figure 6. Effects of CB1R-mediated Ih modulation on LTP.

Figure 6

A–E) Summary plots of the normalized EPSC amplitudes from SPCs before and after LTP induced by theta burst stimulation (TBS) at Schaffer collateral (SC) inputs (TBS-SC-LTP) from (A) WT (n=11), (B) GLU-CB1RKO (n=12), (C) GABA-CBARKO (n=14), (D) HCN1KO (n=13), and (E) JNK1KO (n=12), recorded in control perfusate (CTR, blue) or WIN (red) or AM251 (black). Examples traces were acquired 10min before and 60min after TBS.

F) Summary graphs of % potentiation of EPSC amplitudes 60min after TBS compared to 10min before.

G,H) Summary plots (as in A–E) induced by TBS at temporo-ammonic (TA) inputs (TBS-TA-LTP) in SPCs from WT (G) and HCN1KO (H) mice. Right: Bar graphs of % potentiation of EPSCs. G) Responses in CTR, WIN or AM251 (n: CTR: 11; WIN: 15; AM251: 10). H) Responses in CTR or WIN (n: CTR: 10; WIN: 13).