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. 2016 Jan 14;23(3):263–271. doi: 10.1038/gt.2015.111

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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All AAV serotypes transduce neurons and astrocytes but not microglia and oligodendrocytes in the cortex. Representative cortical images of AAV5, -8, -9 and -rh10 transduced MPS IIIB animals stained for neurons (NeuN), astrocytes (GFAP), microglia (Iba1) and oligodendrocytes (OSP). Arrows indicate areas of co-localization of each cell type and rAAV-GFP in the cortex of MPS IIIB animals. Images taken with × 40 objective lens, scale bar=60 μm.