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. 2016 Jan 14;23(3):263–271. doi: 10.1038/gt.2015.111

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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CNS administered rAAVs also foster differential somatic transduction. Representative organs of 3-month-old control and MPS IIIB-treated animals were tested for somatic transduction of rAAV-GFP in the heart, liver, muscle, kidney and spleen. The presence of rAAV-GFP is indicated by black areas in each tissue section. All tissue sections were scanned at × 20 magnification, scale bar=100 μm.