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Hemagglutinin-specific IgG isotype titers 3 weeks after vaccination of mice with microneedle patches (MN) and unprocessed liquid vaccine injected intramuscularly (IM): IgG2a (a) and IgG1 (b). Microneedle patches and liquid vaccine were stored at 4, 25 or 45°C for 1 month or were stored for 1 day at 4°C. Data show average±s.d. (n=6).
