Table 2.
Results of multivariate logistic regression models predicting MYCN amplification in 7,102 patients with neuroblastoma and known MYCN status.
| Predictor variable (Unfavorable category shown / Favorable category is reference) |
Number of patients
with unfavorable variable / Number of patients with available data |
Odds Ratio for
MYCN Amplification in Presence of Unfavorable Predictor Variable (95% CI) |
P-value |
|---|---|---|---|
| Model A (N=7,102) - All Variables1 | |||
| Age ≥ 18 Months | 3041 / 7102 | 1.5 (1.3–1.8) |
<0.001 |
| Ferritin ≥ 92 (ng/mL) | 1757 / 3602 | 1.6 (1.3–2.1) |
<0.001 |
| LDH ≥ 587 (U/L) | 2114 / 4354 | 5.0 (4.0–6.4) |
<0.001 |
| INSS Stage 4 | 2585 / 7003 | 2.2 (1.9–2.6) |
<0.001 |
| Adrenal Primary Site | 3129 / 6815 | 1.5 (1.3–1.8) |
<0.001 |
| Non-thoracic Primary Site | 5771 / 6815 | 3.5 (2.4–5.1) |
<0.001 |
| Diploid or Hypodiploid | 1025 / 3516 | 2.6 (2.1–3.2) |
<0.001 |
| High MKI | 323 / 2738 | 9.9 (7.2–13.4) |
<0.001 |
| Poorly Differentiated
or Undifferentiated |
2407 / 2871 | 1.9 (1.1–3.1) |
0.014 |
| Chromosome 1p LOH Present |
449 / 2026 | 11.4 (8.2–15.9) |
<0.001 |
| Chromosome 11q Aberration Present |
216 / 1033 | 0.1 (0.06–0.2) |
<0.001 |
| Model B (N=7,102) - Clinical Variables Only1 | |||
| Age ≥ 18 Months | 3041 / 7102 | 1.7 (1.5–2.0) |
<0.001 |
| Ferritin ≥ 92 (ng/mL) | 1757 / 3602 | 1.7 (1.4–2.2) |
<0.001 |
| LDH ≥ 587 (U/L) | 2114 / 4354 | 5.5 (4.4–6.9) |
<0.001 |
| INSS Stage 4 | 2585 / 7003 | 2.7 (2.3–3.1) |
<0.001 |
| Adrenal Primary Site | 3129 / 6815 | 1.6 (1.4–1.9) |
<0.001 |
| Non-thoracic Primary Site | 5771 / 6815 | 3.8 (2.6–5.6) |
<0.001 |
| Model C (N=7,102) - Pathology/Biology Variables Only1 | |||
| Diploid or Hypodiploid | 1025 / 3516 | 3.3 (2.7–4.1) |
<0.001 |
| High MKI | 323 / 2738 | 13.7 (10.2–18.4) |
<0.001 |
| Poorly Differentiated
or Undifferentiated |
2407 / 2871 | 2.6 (1.6–4.3) |
<0.001 |
| Chromosome 1p LOH Present |
449 / 2026 | 17.8 (13.1–24.3) |
<0.001 |
| Chromosome 11q Aberration Present |
216 / 1033 | 0.2 (0.1–0.4) |
<0.001 |
1
Variables tested in the model and found non-significant were: A: Gain of 17q & pooled segmental chromosomal aberration; B: None; C: Gain of 17q & pooled segmental chromosomal aberration.